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Active ingredient:

Atomoxetine

Indications:

The syndrome of deficiency of attention with a hyperactivity (SDVG) at children of 6 years also is more senior, teenagers and adults.

Contraindications:

  • hypersensibility to a preparation;
  • severe damages of heart;
  • simultaneous application with MAO inhibitors;
  • closed-angle glaucoma.

  • With care it is necessary to apply a preparation at patients with arterial hypertension, tachycardia, cardiovascular diseases, heavy physical overloads, simultaneous reception of psychostimulators, sudden warm death in the family anamnesis, violation of brain blood circulation, convulsive attacks in the anamnesis, and also at conditions which can lead to arterial hypotension.

    Application at pregnancy and feeding by a breast:


    Clinical experience of application of Strattera at pregnancy is insufficient therefore it is necessary to appoint a preparation at pregnancy only if the expected advantage of therapy for mother considerably exceeds potential risk for a fruit.

    It isn't known, whether it is allocated buy strattera with chest milk. In need of purpose of a preparation of feeding mother care is required.

    Collateral actions:


    Children and adolescents
    From the digestive system: very common (> 10 %) - abdominal pain (18 %, including the effects of abdominal discomfort, pain, and epigastric discomfort, discomfort in the stomach area ), decreased appetite ( 16%), vomiting ( 11%) and often ( 10.1 %) - constipation, indigestion, nausea ( 9%), and anorexia. These side effects are temporary and usually do not require discontinuation of therapy. Due to reduced appetite in some patients at the beginning of treatment there was a reduction in body weight (average 0.5 kg) body weight loss was greater at higher doses. After the initial weight loss in patients taking Strattera, showed a slight increase in body weight during prolonged therapy. Indicators of growth ( height and weight ) after two years of treatment were close to normal.
    Nausea ( 9%) and vomiting ( 11% ) are most likely to occur in the first month of treatment, usually of mild to moderate severity, are temporary and do not cause discontinuation of treatment in a significant number of cases.
    Cardio - vascular system: ( 0.1-1 %) - palpitations, sinus tachycardia.
    In placebo - controlled trials in children treated with Strattera, noted an average increase in heart rate of 6 beats / min, and the average increase in SBP and DBP - 2 mm Hg compared with placebo.
    Patients treated with atomoxetine, orthostatic hypotension observed (0,2%, n = 7) and syncope (0,8%, n = 26), due to its effects on noradrenergic tone.
    CNS: very common ( > 10%) - somnolence (including sedation ), often ( 10.1 %) - irritability, mood swings, dizziness, and sometimes ( 0.1-1 %) - Early morning awakening.
    Part of the vision: common ( 1-10 %) - mydriasis.
    Dermatological reactions: often ( 10.1 %) - dermatitis, rashes, and sometimes ( 0.1-1 %) - itching.
    Other: often ( 10.1 %) - a flu, fatigue, weight loss, and sometimes ( 0.1-1 %) - weakness.
    Side effects in patients with a slow metabolism of substrates CYP2D6, observed in 2 % of cases, while in 2 times more often, and also statistically significantly more frequently than in patients with a rapid metabolism of substrates of CYP2D6: tremor ( 5.1 and 1.1%, respectively), syncope ( 2.1 and 0.7 %, respectively), conjunctivitis (3 and 1.5% respectively), early morning awakening (3 and 1.1% respectively), mydriasis (2.5 and 0.7 %, respectively).

    Adults

    In adults, the most common side effects associated with taking atomoxetine were noted from the gastrointestinal tract and urogenital tract. No serious adverse events during a short or long-term treatment atomoxetine was not observed.
    From the digestive system: very common (> 10 %) - decreased appetite, dry mouth, nausea, frequent ( 10.1 %) - abdominal pain ( including the effects of abdominal discomfort, pain, and epigastric discomfort, discomfort in the stomach area ), constipation, dyspepsia, flatulence.
    CNS: very common ( > 10%) - insomnia ( difficulty falling asleep and include sleep disturbance during the night ), and often ( 10.1 %) - decreased libido, dizziness, impaired sleep quality, sinus headache, and sometimes ( 0.1 -1% ) - Early morning awakening.
    Cardio - vascular system: common (1-10 %) - flushing, palpitations, tachycardia, and sometimes ( 0.1-1 %) - the feeling of cold in the lower extremities, very rare ( <0.01 %) according to the spontaneous ( postmarketing reports ) - peripheral vascular responses and / or Raynaud's syndrome and the risk of recurrence of Raynaud's syndrome.
    In a placebo - controlled studies in adults treated with Strattera, the average increase in heart rate observed at 6 beats / min SBP average increase (about 3 mmHg ) and diastolic blood pressure (about 1 mmHg ) compared to placebo.
    The urinary system: common (1-10 %) - dysuria, difficulty in urination.
    Part of the reproductive system: common (1-10 %) - dysmenorrhea, abnormal ejaculation, lack of ejaculation, erectile dysfunction, erectile dysfunction, menstrual disorders, impaired orgasm, very rare ( <0.01 %), according to the spontaneous ( postmarketing ) messages - a painful or prolonged erection.
    Skin and subcutaneous tissue often ( 10.1 %) - dermatitis, excessive sweating.
    Other: often ( 10.1 %) - weakness, drowsiness, vomiting, weight loss.

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